Outcome of PREDIMED Study has been published in the New England Journal of Medicine that examined primary prevention of cardiovascular disease with Mediterranean diet. The result has been shown that Mediterranean diet with extra-virgin olive oil or mixed nuts has better prognosis than reduction of lipid. It is considered that alpha linolenic acid rich Mediterranean diet, a component of walnuts, influences oxidative stress, inflammation or endothelial dysfunction. <\/p>\n

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet<\/h1>\n
Ram\u00f3n Estruch, M.D., Ph.D., Emilio Ros, M.D., Ph.D., Jordi Salas-Salvad\u00f3, M.D., Ph.D., Maria-Isabel Covas, D.Pharm., Ph.D., Dolores Corella, D.Pharm., Ph.D., Fernando Ar\u00f3s, M.D., Ph.D., Enrique G\u00f3mez-Gracia, M.D., Ph.D., Valentina Ruiz-Guti\u00e9rrez, Ph.D., Miquel Fiol, M.D., Ph.D., Jos\u00e9 Lapetra, M.D., Ph.D., Rosa Maria Lamuela-Raventos, D.Pharm., Ph.D., Llu\u00eds Serra-Majem, M.D., Ph.D., Xavier Pint\u00f3, M.D., Ph.D., Josep Basora, M.D., Ph.D., Miguel Angel Mu\u00f1oz, M.D., Ph.D., Jos\u00e9 V. Sorl\u00ed, M.D., Ph.D., Jos\u00e9 Alfredo Mart\u00ednez, D.Pharm, M.D., Ph.D., and Miguel Angel Mart\u00ednez-Gonz\u00e1lez, M.D., Ph.D., for the PREDIMED Study Investigators<\/p>\n
N Engl J Med 2013;368:1279-90<\/a><\/p>\n

Background<\/h3>\n
Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.<\/p>\n
Methods<\/h3>\n
In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Participants received quarterly individual and group educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. The primary end point was the rate of major cardiovascular events (myocardial infarction, stroke, or death from cardiovascular causes). On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4.8 years.<\/p>\n
Results <\/h3>\n
A total of 7447 persons were enrolled (age range, 55 to 80 years); 57% were women. The two Mediterranean-diet groups had good adherence to the intervention, according to self-reported intake and biomarker analyses. A primary end-point event occurred in 288 participants. The multivariable-adjusted hazard ratios were 0.70 (95% confidence interval [CI], 0.54 to 0.92) and 0.72 (95% CI, 0.54 to 0.96) for the group assigned to a Mediterranean diet with extra-virgin olive oil (96 events) and the group assigned to a Mediterranean diet with nuts (83 events), respectively, versus the control group (109 events). No diet-related adverse effects were reported.<\/p>\n
Conclusions<\/h3>\n
Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.<\/p>\n
References:
\n Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors<\/a>
\n Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome<\/a>
\n Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"
Outcome of PREDIMED Study has been published in the New England Journal of Medicine that examined primary prev … “Primary Prevention of Cardiovascular Disease with a Mediterranean Diet” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":6031,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[11,4],"tags":[159,161,160,162,158],"class_list":["post-2475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthcare","category-nutrition","tag-cardiovascular-disease","tag-extra-virgin-olive-oil","tag-mediterranean-diet","tag-mixed-nuts","tag-primary-prevention"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/posts\/2475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2475"}],"version-history":[{"count":25,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/posts\/2475\/revisions"}],"predecessor-version":[{"id":7721,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/posts\/2475\/revisions\/7721"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=\/wp\/v2\/media\/6031"}],"wp:attachment":[{"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fujiitoshiki.com\/improvesociety\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Conclusions<\/h3>\nAmong persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.<\/p>\n