\u3000\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u304c\u3044\u304b\u306a\u308b\u6a5f\u5e8f\u3067\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306b\u95a2\u9023\u3059\u308b\u708e\u75c7\u72b6\u614b\u3092\u6e1b\u5c11\u3055\u305b\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u304c\uff0c\u767d\u8840\u7403\u6d3b\u6027\u5316\u3068\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3092\u901a\u3058\u3066\uff0cCRP \u304c\u76f4\u63a5\u75c5\u5909\u5f62\u6210\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n

\u3000\u8003\u5bdf\u306e\u6587\u4e2d\u306e\u4e38\u62ec\u5f27\u306f\u53c2\u8003\u6587\u732e\u306e\u756a\u53f7\u3067\u3059\uff0e\u548c\u8a33\u306e\u7455\u75b5\u306e\u8cac\u4efb\u306f\u79c1\u306b\u3042\u308a\u307e\u3059\u304c\uff0c\u3053\u306e\u8a18\u4e8b\u306e\u5229\u7528\u306b\u95a2\u3059\u308b\u8cac\u4efb\u306f\u5404\u81ea\u3067\u304a\u9858\u3044\u3057\u307e\u3059\uff0e<\/p>\n

\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3068\u8840\u7ba1\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u306b\u5bfe\u3059\u308b\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306e\u5f71\u97ff<\/a><\/h2>\n
\u7121\u4f5c\u70ba\u5316\u8a66\u9a13<\/h3>\n
Katherine Esposito, MD; Raffaele Marfella, MD, PhD; Miryam Ciotola, MD; Carmen Di Palo, MD; Francesco Giugliano, MD; Giovanni Giugliano, MD; Massimo D\u2019Armiento, MD; Francesco D\u2019Andrea, MD; Dario Giugliano, MD, PhD<\/p>\n
\u80cc\u666f<\/strong>\u3000\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6e1b\u5c11\u3055\u305b\u308b\u98df\u4e8b\u7642\u6cd5\u306e\u76ee\u6a19\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u75ab\u5b66\u306b\u304a\u3044\u3066\u98df\u4e8b\u306e\u5f79\u5272\u306f\u307b\u3068\u3093\u3069\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\uff0e<\/p>\n
\u5bfe\u8c61<\/strong>\u3000\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306e\u5185\u76ae\u6a5f\u80fd\u3068\u8840\u7ba1\u708e\u75c7\u6027\u30de\u30fc\u30ab\u30fc\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\uff0e<\/p>\n
\u30c7\u30b6\u30a4\u30f3\uff0c\u8a2d\u5b9a\uff0c\u60a3\u8005<\/strong>\u3000\u7121\u4f5c\u70ba\u5316\u3057\u305f\u5358\u76f2\u691c\u8a66\u9a13\u304c 2001 \u5e746\u6708\u304b\u3089 2004\u5e741\u6708\u307e\u3067\u5927\u5b66\u75c5\u9662\u306b\u304a\u3044\u3066\u6210\u4eba\u6cbb\u7642\u30d1\u30cd\u30eb III \u306b\u3088\u3063\u3066\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3059\u308b\u3068\u540c\u5b9a\u3055\u308c\u305f\u60a3\u8005180 \u540d\uff08\u7537\u6027 99 \u540d\uff0c\u5973\u6027 81 \u540d\uff09\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3055\u308c\u305f\uff0e<\/p>\n
\u4ecb\u5165<\/strong>\u3000\u4ecb\u5165\u7fa4\u60a3\u8005 (n=90) \u306f\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306b\u5f93\u3046\u3088\u3046\u6307\u793a\u3055\u308c\uff0c\u5168\u7c92\u7a40\u7269\uff0c\u679c\u5b9f\u985e\uff0c\u91ce\u83dc\u985e\uff0c\u30ca\u30c3\u30c4\u985e\uff0c\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u65e5\u3005\u306e\u6d88\u8cbb\u3092\u3069\u3046\u3084\u3063\u3066\u5897\u3084\u3059\u304b\u306b\u3064\u3044\u3066\u306e\u8a73\u7d30\u306a\u6307\u5c0e\u3092\u53d7\u3051\u305f\uff0e\u5bfe\u7167\u7fa4\u60a3\u8005 (n=90) \u306f\u614e\u91cd\u306a\u98df\u4e8b\uff08\u70ad\u6c34\u5316\u7269 50% – 60%; \u86cb\u767d\u8cea 15% – 20%; \u7dcf\u8102\u8cea 30% \u672a\u6e80\uff09\u306b\u5f93\u3063\u305f\uff0e<\/p>\n
\u4e3b\u306a\u8ee2\u5e30\u306e\u6307\u6a19<\/strong>\u3000\u6804\u990a\u6442\u53d6\uff0e\u8840\u5727\u3068L-\u30a2\u30eb\u30ae\u30cb\u30f3\u306b\u5bfe\u3059\u308b\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5fdc\u3068\u3057\u3066\u306e\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\uff0e\u8102\u8cea\u3068\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u5909\u6570\uff0e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\uff0e\u5faa\u74b0\u8840\u6f3f\u4e2d\u306e\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d (hs-CRP)\u3068\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36 (IL-6), \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f37 (IL-7), \u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3 18 (IL-18)\uff0e<\/p>\n
\u7d50\u679c<\/strong>\u30002\u5e74\u5f8c\uff0c\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306b\u5f93\u3063\u305f\u60a3\u8005\u3067\u306f\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff0c\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff0c\u98df\u7269\u7e4a\u7dad\uff0c\u03c9-3\u8102\u80aa\u9178\u306b\u5bfe\u3059\u308b\u03c9-6\u8102\u80aa\u9178\u306e\u6bd4\u7387\u306a\u3069\u306b\u304a\u3044\u3066\u3088\u308a\u8c4a\u5bcc\u306b\u98df\u7269\u3092\u6d88\u8cbb\u3057\u3066\u3044\u305f\uff0e\u3042\u3089\u3086\u308b\u679c\u5b9f\u985e\uff0c\u91ce\u83dc\u985e\uff0c\u30ca\u30c3\u30c4\u985e (274 g\/d) \u306e\u6442\u53d6\uff0c\u5168\u7c92\u7a40\u7269 (103 g\/d), \u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u6d88\u8cbb (8 g\/d) \u3082\u307e\u305f\u4ecb\u5165\u7fa4\u3067\u306f\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f (P < 0.001)\uff0e\u8eab\u4f53\u6d3b\u52d5\u30ec\u30d9\u30eb\u306f\u4e21\u7fa4\u3068\u3082\u306b 60% \u8fd1\u304f\u5897\u52a0\u3057\u3066\u3044\u305f\u304c\uff0c\u7fa4\u9593\u3067\u306e\u5dee\u7570\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f (P = 0.22)\uff0e\u4f53\u91cd\u306e\u5e73\u5747\u5024\u3068\u6a19\u6e96\u504f\u5dee\u306f\u305d\u308c\u305e\u308c \u2013 4.0 [1.1] kg, - 1.2 [0.6] kg\u3067\u3042\u308a\uff0c\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u4ecb\u5165\u7fa4\u3067\u3088\u308a\u6e1b\u5c11\u3057\u3066\u3044\u305f (P < 0.001)\uff0e\u5bfe\u8c61\u98df\u4e8b\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\uff0c\u4ecb\u5165\u98df\u6d88\u8cbb\u7fa4\u3067\u306f\u9ad8\u611f\u5ea6 CRP (P = 0.01), IL-6 (P = 0.04), IL-7 (P = 0.4), IL-18 (P = 0.3) \u304c\u4f4e\u4e0b\u3057\u3066\u304a\u308a\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3082\u6e1b\u5c11\u3057\u3066\u3044\u305f (P < 0.001)\uff0e\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2 (mean [SD]) \u306f\u4ecb\u5165\u7fa4\u3067\u306f\u6539\u5584\u304c\u898b\u3089\u308c\u305f (+ 1.9 [0.6]; P < 0.001) \u304c\uff0c\u5bfe\u7167\u7fa4\u3067\u306f\u5909\u5316\u3057\u306a\u3044\u307e\u307e (+ 0.2 [0.2]; P = 0.33) \u3067\u3042\u3063\u305f\uff0e2\u5e74\u9593\u306e\u7d4c\u904e\u89b3\u5bdf\u6642\u70b9\u3067\u4ecb\u5165\u7fa4\u306e\u60a3\u8005\u3067\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u57fa\u6e96\u3092\u6e80\u305f\u3059\u60a3\u8005\u306f40 \u540d\u306b\u904e\u304e\u306a\u304b\u3063\u305f\u304c\uff0c\u5bfe\u7167\u7fa4\u60a3\u8005\u3067\u306f 78 \u540d\u3067\u3042\u3063\u305f (P < 0.001)\uff0e<\/p>\n
\u7d50\u8ad6<\/strong>\u3000\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3068\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u306e\u6709\u75c5\u7387\u3092\u6e1b\u5c11\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e<\/p>\n
JAMA. 2004; 292: 1440-1446<\/h3>\n
\u3000\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30682\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3092\u5897\u3084\u3059\u56e0\u5b50\u306e\u96c6\u5408\u304b\u3089\u306a\u308b\uff0e\u6700\u8fd1\u306e\u63a8\u5b9a\u3067\u306f\u5408\u8846\u56fd\u306b\u304a\u3044\u3066\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306f\u4e00\u822c\u7684\u3067\u3042\u308b\u3068\u3055\u308c\uff0c\u6210\u4eba\u4eba\u53e3\u306e 24% \u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u81e8\u5e8a\u7684\u540c\u5b9a\u65b9\u6cd5\u306f\u8179\u90e8\u80a5\u6e80\u306e\u8179\u56f2\u6e2c\u5b9a\uff0c\u52d5\u8108\u786c\u5316\u6027\u8102\u8cea\u7570\u5e38\uff0c\u8840\u5727\u4e0a\u6607\uff0c\u8010\u7cd6\u80fd\u7570\u5e38\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\uff0e\u672c\u75c7\u5019\u7fa4\u306e\u6210\u56e0\u306f\u5927\u304d\u3059\u304e\u3066\u4e0d\u660e\u3060\u304c\uff0c\u6050\u3089\u304f\u907a\u4f1d\u56e0\u5b50\uff0c\u4ee3\u8b1d\u56e0\u5b50\uff0c\u98df\u4e8b\u3092\u542b\u3080\u74b0\u5883\u56e0\u5b50\u306e\u8907\u96d1\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u8868\u3057\u3066\u3044\u308b\uff0e\u6700\u8fd1\u306e\u5e7e\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\uff0c\u708e\u75c7\u72b6\u614b\u3082\u307e\u305f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u793a\u3055\u308c\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0c\u4f4e\u30ec\u30d9\u30eb\u306e\u708e\u75c7\u304c\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u84c4\u7a4d\u3057\u3064\u3064\u3042\u308b\uff0e<\/p>\n
\u3000\u98df\u4e8b\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u500b\u3005\u306e\u7279\u5fb4\u306b\u7e4b\u304c\u308b\u89b3\u70b9\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0c\u672c\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u3068\u3057\u3066\u306e\u98df\u4e8b\u306e\u5f79\u5272\u306f\u6b86\u3069\u7406\u89e3\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u5c11\u6570\u306e\u89b3\u5bdf\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u306b\u904e\u304e\u306a\u3044\uff0e\u6210\u4eba\u6cbb\u7642\u30d1\u30cd\u30eb III \u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3059\u308b\u60a3\u8005\u3078\u306e\u63a8\u5968\u306f\u4e00\u822c\u7684\u306a\u98df\u4e8b\u306e\u63a8\u5968\u304b\u3089\u306a\u308b\uff0e\u6700\u8fd1\u30a2\u30e1\u30ea\u30ab\u5fc3\u81d3\u75c5\u5b66\u4f1a\u306e\u79d1\u5b66\u8aee\u554f\u59d4\u54e1\u4f1a\u306f\uff0c\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u9032\u5c55\u306b\u5bfe\u3057\u3066\u5370\u8c61\u7684\u306a\u52b9\u679c\u3092\u6709\u3059\u308b\u3068\u8ff0\u3079\u305f\uff0e<\/p>\n
\u3000\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\uff0c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3044\u3066\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3068\u8840\u7ba1\u708e\u75c7\u3068\u306b\u5bfe\u3059\u308b\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\uff0e\u6211\u3005\u306f L-\u30a2\u30eb\u30ae\u30cb\u30f3\uff0c\u3064\u307e\u308a\u4e00\u9178\u5316\u7a92\u7d20\u306e\u81ea\u7136\u306e\u524d\u99c6\u4f53\u306a\u306e\u3060\u304c\uff0c\u3053\u308c\u306b\u5bfe\u3059\u308b\u8840\u7ba1\u306e\u53cd\u5fdc\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u5185\u76ae\u6a5f\u80fd\u3092\u7814\u7a76\u3057\u305f\uff0e\u66f4\u306b\u6211\u3005\u306f\u4f8b\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u60a3\u8005\u306e\u4f4e\u30ec\u30d9\u30eb\u306e\u708e\u75c7\u72b6\u614b\u3092\uff0c\u5faa\u74b0\u8840\u6f3f\u4e2d\u306e\u9ad8\u611f\u5ea6 CRP \u306e\u4ed6 IL-6, IL-7, IL-18 \u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u7279\u5fb4\u3065\u3051\u305f\uff0e\u3053\u308c\u3089\u306e\u524d\u708e\u75c7\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u306f\u6050\u3089\u304f\u8840\u6813\u6027\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u304b (16, 17)\uff0c\u30d7\u30e9\u30fc\u30af\u306e\u4e0d\u5b89\u5b9a\u5316\u3078\u306e\u95a2\u4e0e\u3092\u793a\u5506\u3055\u308c\u3066\u3044\u308b (18)\uff0e\u305d\u3053\u3067\u6211\u3005\u306f\uff0c\u690d\u7269\u6027\u5316\u5b66\u7269\u8cea\uff0c\u6297\u9178\u5316\u5264\uff0c\u03b1\u30ea\u30ce\u30ec\u30f3\u9178\uff0c\u98df\u7269\u7e4a\u7dad\u306b\u5bcc\u3080\u98df\u54c1\u306e\u6d88\u8cbb\u3092\u5897\u3084\u3059\u3088\u3046\u306b\u30c7\u30b6\u30a4\u30f3\u3057\u305f\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3092\u884c\u3063\u305f\uff0e<\/p>\n
\u65b9\u6cd5<\/h3>\n
\u30002001 \u5e746\u6708\u304b\u3089 2004 \u5e741\u6708\u307e\u3067\u306e\u9593\u306b\uff0c\u30a4\u30bf\u30ea\u30a2\u306e\u30ca\u30d7\u30ec\u30b9\u306e\u30ca\u30d7\u30ec\u30b9\u7b2c2\u5927\u5b66\u4ee3\u8b1d\u75be\u75c5\u90e8\u9580\u306e\u5916\u6765\u306b\u901a\u9662\u3059\u308b\u7537\u5973\u304b\u3089\u53c2\u52a0\u8005\u3092\u63a1\u7528\u3057\u305f\uff0e\u672c\u7814\u7a76\u306e\u53c2\u52a0\u8005\u306f\u5750\u4f4d\u52dd\u3061\uff081\u9031\u9593\u306e\u8eab\u4f53\u904b\u52d5\u304c1\u6642\u9593\u672a\u6e80\uff09\u3067\u904e\u53bb6\u30f6\u6708\u4ee5\u5185\u306b\u4f53\u91cd\u6e1b\u5c11\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u53c2\u52a0\u3057\u305f\u8a3c\u62e0\u304c\u306a\u304f\uff0c\u5b89\u5b9a\u3057\u305f\u4f53\u91cd (+- 1 kg) \u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u4eba\u3005\u3067\u3042\u3063\u305f\uff0e\u6804\u990a\u306e\u7814\u7a76\u306b\u5f93\u4e8b\u3057\u3066\u3044\u308b\u53c2\u52a0\u8005\u306f\u4e00\u4eba\u3082\u3044\u306a\u304b\u3063\u305f\uff0e\u5404\u3005\u306e\u60a3\u8005\u306f\u5b8c\u5168\u306a\u500b\u4eba\u7684\u5065\u5eb7\u72b6\u614b\u3068\u75c5\u6b74\u306b\u95a2\u3059\u308b\u30a2\u30f3\u30b1\u30fc\u30c8\u3092\u53d7\u3051\u305f\uff0e\u3053\u308c\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c4\u30fc\u30eb\u3068\u3057\u3066\u5f79\u7acb\u3063\u305f\uff0e<\/p>\n
\u3000\u672c\u8a66\u9a13\u306b\u767b\u9332\u3059\u308b\u306b\u306f\u60a3\u8005\u306f\u4ee5\u4e0b\u306b\u793a\u3059\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u57fa\u6e96\u306e3\u3064\u4ee5\u4e0a\u3092\u6709\u3057\u3066\u3044\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u304b\u3063\u305f\uff0e\u6210\u4eba\u6cbb\u7642\u30d1\u30cd\u30eb III \u306b\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u308b\u304c\uff0c(1) \u5185\u81d3\u8102\u80aa\uff08\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u304c\u7537\u6027\u3067 102 cm\u3000\u3088\u308a\u5927\uff0c\u5973\u6027\u3067 88 cm \u3088\u308a\u5927\u3068\u5b9a\u7fa9\uff09\uff0e(2) \u8840\u6e05 HDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\uff08\u7537\u6027\u3067 40 mg\/dL \u672a\u6e80\uff0c\u5973\u6027\u3067 50 mg\/dL \u672a\u6e80\uff09\uff0e(3) \u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\uff08\u4e2d\u6027\u8102\u80aa\u5024\u304c 150 mg\/dL \u4ee5\u4e0a\uff09\uff0e(4) \u8840\u5727\u4e0a\u6607\uff08130\/85 mm Hg \u4ee5\u4e0a\uff09\uff0e(5) \u8010\u7cd6\u80fd\u7570\u5e38\uff08\u7a7a\u8179\u6642\u8840\u7cd6\u5024 110 mg\/dL \u4ee5\u4e0a\uff09\uff0e\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3066\u3044\u308b\u304b\uff0c\u7cbe\u795e\u7684\u554f\u984c\u304c\u3042\u308b\u304b\uff0c\u30a2\u30eb\u30b3\u30fc\u30eb\u4e2d\u6bd2\u306e\u65e2\u5f80\uff08\u904e\u53bb1\u5e74\u4ee5\u5185\u306b1\u9031\u9593\u306b 500 g \u4ee5\u4e0a\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6d88\u8cbb\uff09\u304c\u3042\u308b\u304b\uff0c\u55ab\u7159\u6b74\u304c\u3042\u308b\u304b\uff0c\u4f55\u3089\u304b\u306e\u85ac\u7269\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u9664\u5916\u3057\u305f\uff0e\u672c\u8a66\u9a13\u306f\u30ca\u30d7\u30ec\u30b9\u7b2c2\u5927\u5b66\u502b\u7406\u59d4\u54e1\u4f1a\u304c\u627f\u8a8d\u3057\uff0c\u5168\u60a3\u8005\u304c\u66f8\u9762\u3067\u540c\u610f\u3057\u305f\uff0e<\/p>\n
\u3000\u60a3\u8005\u306f\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3067\u767a\u751f\u3055\u305b\u305f\u4e71\u6570\u5217\u3092\u7528\u3044\u3066\u4ecb\u5165\u7fa4\u304b\u5bfe\u7167\u7fa4\u306e\u3044\u305a\u308c\u304b\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f (Figure 1<\/strong>)\uff0e\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30b3\u30f3\u30bb\u30f3\u30c8\u304c\u6e08\u3093\u3060\u5f8c\uff0c\u4e2d\u592e\u306e\u5b89\u5168\u306a\u5834\u6240\u3067\u5272\u4ed8\u3092\u884c\u3044\uff0c\u5bc6\u5c01\u3057\u305f\u30d5\u30a9\u30eb\u30c0\u306e\u4e2d\u306b\u96a0\u853d\u3057\u305f\uff0e\u8a2a\u554f\u3092\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3057\u305f\u770b\u8b77\u5e2b\u306f\u7121\u4f5c\u70ba\u5316\u30ea\u30b9\u30c8\u306b\u95a2\u4e0e\u3057\u306a\u304b\u3063\u305f\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u4ecb\u5165\u306b\u95a2\u4e0e\u3057\u305f\u8077\u54e1\u306f\u5272\u4ed8\u306e\u7fa4\u306b\u6ce8\u610f\u305b\u3056\u308b\u3092\u5f97\u306a\u304b\u3063\u305f\uff0e\u305d\u3053\u3067\uff0c\u672c\u8a66\u9a13\u306f\u4e00\u90e8\u76f2\u691c\u5316\u3057\u305f\u3082\u306e\u3068\u306a\u3063\u305f\uff0e\u691c\u67fb\u90e8\u9580\u306e\u8077\u54e1\u306f\u60a3\u8005\u306e\u7fa4\u5272\u4ed8\u3092\u77e5\u3089\u306a\u304b\u3063\u305f\uff0e<\/p>\n
\u3000\u4f8b\u306e\u4ecb\u5165\u98df\u3092\u6d88\u8cbb\u3059\u308b\u60a3\u8005\u306f\u4f1d\u7d71\u6599\u7406\u306e\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u8a73\u7d30\u306a\u6307\u5c0e\u3092\u53d7\u3051\u305f\uff0e\u6708\u306b\u4e00\u56de\u306e\u5c11\u4eba\u6570\u3067\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u3092\u7d4c\u3066\uff0c\u4ecb\u5165\u7fa4\u60a3\u8005\u306f\u98df\u4e8b\u30ab\u30ed\u30ea\u30fc\u3092\uff08\u5fc5\u8981\u304c\u3042\u308c\u3070\uff09\u6e1b\u3089\u3059\u3053\u3068\uff0c\u500b\u4eba\u306e\u76ee\u6a19\u3092\u8a2d\u5b9a\u3059\u308b\u3053\u3068\uff0c\u98df\u4e8b\u65e5\u8a18\u3092\u4ed8\u3051\u3066\u30bb\u30eb\u30d5\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u306e\u6559\u80b2\u3092\u53d7\u3051\u305f\uff0e\u884c\u52d5\u7cbe\u795e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3082\u63d0\u4f9b\u3055\u308c\u305f\uff0e 3\u65e5\u9593\u306e\u98df\u4e8b\u8a18\u9332\u306b\u57fa\u3065\u3044\u3066\u500b\u3005\u306e\u60a3\u8005\u306b\u5408\u308f\u305b\u3066\u98df\u4e8b\u6307\u5c0e\u3092\u8abf\u6574\u3057\u305f\uff0e\u63a8\u5968\u3055\u308c\u308b\u98df\u4e8b\u7642\u6cd5\u306e\u6210\u5206\u306f\u4ee5\u4e0b\u306e\u901a\u308a\uff0e\u70ad\u6c34\u5316\u7269 50% \u304b\u3089 60%\uff0e\u86cb\u767d\u8cea 15% \u304b\u3089 20%\uff0e\u7dcf\u8102\u8cea 30% \u672a\u6e80\uff0e\u98fd\u548c\u8102\u80aa\u9178 10% \u672a\u6e80\uff0e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6d88\u8cbb\u306f1\u65e5 300 mg \u672a\u6e80\uff0e\u3055\u3089\u306b\u60a3\u8005\u306f1\u65e5\u3054\u3068\u306b\u6700\u4f4e 250 g \u304b\u3089 300 g \u306e\u679c\u5b9f\u985e\uff0c125 g \u304b\u3089 150 g \u306e\u91ce\u83dc\u985e\uff0c25 g \u304b\u3089 50 g \u306e\u30af\u30eb\u30df\u3092\u6d88\u8cbb\u3059\u308b\u3088\u3046\u306b\u6307\u5c0e\u3055\u308c\u305f\uff0e\u52a0\u3048\u30661\u65e5\u3054\u3068\u306b 400 g \u306e\u5168\u7c92\u7a40\u7269\uff08\u30de\u30e1\uff0c\u30b3\u30e1\uff0c\u30c8\u30a6\u30e2\u30ed\u30b3\u30b7\uff0c\u5c0f\u9ea6\uff09\u3092\u6d88\u8cbb\u3059\u308b\u3053\u3068\uff0c\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u6d88\u8cbb\u3092\u5897\u3084\u3059\u3053\u3068\u3092\u63a8\u5968\u3055\u308c\u305f\uff0e\u60a3\u8005\u306f24\u30f6\u6708\u9593\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u5f93\u4e8b\u3057\uff0c1\u5e74\u76ee\u306f\u6bce\u6708\uff0c2\u5e74\u76ee\u306f2\u30f6\u6708\u3054\u3068\u306b\u6804\u990a\u30bb\u30c3\u30b7\u30e7\u30f3\u3092\u958b\u50ac\u3057\u305f\uff0e\u30d7\u30ed\u30b0\u30e9\u30e0\u3078\u306e\u6e96\u62e0\u306f\u4f1a\u5408\u3078\u306e\u51fa\u5e2d\u3068\u98df\u4e8b\u65e5\u8a18\u306e\u5fb9\u5e95\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3057\u305f\uff0e<\/p>\n
\u3000\u5bfe\u7167\u98df\u4e8b\u3092\u6d88\u8cbb\u3059\u308b\u60a3\u8005\u306f\u4e00\u822c\u306b\u53e3\u982d\u53c8\u306f\u6587\u66f8\u3067\uff0c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u5065\u5eb7\u7684\u306a\u98df\u54c1\u306e\u9078\u629e\u306b\u3064\u3044\u3066\u306e\u60c5\u5831\u3092\u53d7\u3051\u305d\u306e\u5f8c\u8a2a\u554f\u3092\u53d7\u3051\u305f\u304c\uff0c\u500b\u4eba\u7684\u306a\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u63d0\u4f9b\u306f\u53d7\u3051\u306a\u304b\u3063\u305f\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u4e00\u822c\u7684\u306b\u63a8\u5968\u3055\u308c\u308b\u98df\u4e8b\u306e\u4e3b\u8981\u6804\u990a\u7d20\u306e\u7d44\u6210\u306f\u4ecb\u5165\u7fa4\u306e\u305d\u308c\u3068\u8fd1\u4f3c\u3057\u3066\u3044\u305f\uff08\u70ad\u6c34\u5316\u7269 50% \u304b\u3089 60%\uff0c\u86cb\u767d\u8cea 15% \u304b\u3089 20%\uff0c\u7dcf\u8102\u8cea 30% \u672a\u6e80\uff09\uff0e\u3055\u3089\u306b\u5bfe\u7167\u7fa4\u306e\u60a3\u8005\u306f2\u5e74\u9593\u306e\u8a66\u9a13\u671f\u9593\u4e2d\uff0c2\u30f6\u6708\u3054\u3068\u306b\u500b\u4eba\u7684\u306b\u52c9\u5f37\u4f1a\u306b\u3082\u53c2\u52a0\u3057\u305f\uff0e\u4e21\u7fa4\u306e\u5168\u60a3\u8005\u306f\u8eab\u4f53\u6d3b\u52d5\u30ec\u30d9\u30eb\u3092\u5897\u3084\u3059\u624b\u5f15\u304d\u3092\u53d7\u3051\u53d6\u308a\uff0c1\u65e5\u306b30\u5206\u9593\uff0c\u4e3b\u306b\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3060\u304c\u305d\u308c\u3060\u3051\u3067\u306a\u304f\u6c34\u6cf3\u3084\u6709\u9178\u7d20\u7403\u6280\uff08\u30b5\u30c3\u30ab\u30fc\u306a\u3069\uff09\u3092\u884c\u3063\u305f\uff0e<\/p>\n
\u3000\u8eab\u9577\u3068\u4f53\u91cd\u306f\u53c2\u52a0\u8005\u304c\u8efd\u88c5\u3067\u9774\u3092\u8131\u3044\u3060\u72b6\u614b\u3067 Seca 200 \u4f53\u91cd\u8a08\u3068\u305d\u308c\u306b\u4ed8\u5c5e\u3059\u308b\u8eab\u9577\u6e2c\u5b9a\u5668\u3067\u6e2c\u5b9a\u3057\u305f\uff0e24\u6642\u9593\u306e\u6804\u990a\u6442\u53d6\u91cf\u306f\u98df\u54c1\u6210\u5206\u8868\u3068\u60a3\u8005\u306e\u9031\u3054\u3068\u306e\u98df\u4e8b\u8a18\u9332\u304b\u3089\u8a08\u7b97\u3057\u305f\uff0e\u98df\u4e8b\u306e\u9806\u5b88\u3068\u904b\u52d5\u6d3b\u52d5\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\uff0c\u3059\u3079\u3066\u306e\u53c2\u52a0\u8005\u306b3\u65e5\u9593\u306e\u5b8c\u5168\u306a\u8a18\u9332\uff0c\u3064\u307e\u308a\u98df\u4e8b\u8a18\u9332\u304a\u3088\u3073\u5c31\u696d\u4e2d\u306e\u8eab\u4f53\u6d3b\u52d5\uff0c\u5bb6\u4e8b\u306e\u8eab\u4f53\u6d3b\u52d5\uff0c\u4f59\u6687\u6642\u9593\u306e\u8eab\u4f53\u6d3b\u52d5\u306e\u5b8c\u5168\u306a\u8a18\u9332\u3092\u6c42\u3081\u305f\uff0e\u98df\u4e8b\u306f\u6a19\u6e96\u8a08\u91cf\u30ab\u30c3\u30d7\u3068\u30b9\u30d7\u30fc\u30f3\u304a\u3088\u3073\u91cd\u91cf\u306e\u8fd1\u4f3c\u30c0\u30a4\u30a2\u30b0\u30e9\u30e0\u3067\u8a08\u91cf\u3057\u305f\uff0e<\/p>\n
\u5185\u76ae\u6a5f\u80fd<\/h3>\n
\u3000\u5185\u76ae\u6a5f\u80fd\u306f\u524d\u8ff0\u3057\u305f\u3088\u3046\u306b L-\u30a2\u30eb\u30ae\u30cb\u30f3\u30c6\u30b9\u30c8\u306b\u3088\u308a\u8a55\u4fa1\u3057\u305f\uff0e\u624b\u77ed\u306b\u8ff0\u3079\u308b\u3068\uff0c\u8840\u5727\u3068\u5fc3\u62cd\u6570\u306e\u81ea\u52d5\u6e2c\u5b9a\u88c5\u7f6e (Omheda 2300; Finalpres, Englewood, Calif) \u306b\u304b\u3051\u305f\u5f8c\uff0c\u8840\u7ba1\u5185\u306b 3g \u306eL-\u30a2\u30eb\u30ae\u30cb\u30f3\uff08L-\u30a2\u30eb\u30ae\u30cb\u30f3\u5869\u5316\u7269\u306e 30% \u6eb6\u6db2 10 mL\uff09\uff0c\u3053\u308c\u306f\u4e00\u9178\u5316\u7a92\u7d20\u306e\u81ea\u7136\u524d\u99c6\u4f53\u3067\u3042\u308b\u304c\uff0c\u3053\u308c\u3092 60 \u79d2\u4ee5\u5185\u306b\u6025\u901f\u9759\u6ce8\u3057\u305f\uff0eL-\u30a2\u30eb\u30ae\u30cb\u30f3\u9759\u6ce8\u524d\u3068\u6295\u4e0e 10 \u5206\u5f8c\u306e 1.25 microM \u30a2\u30c7\u30ce\u30b7\u30f3\uff12\u30ea\u30f3\u9178\u306b\u5bfe\u3059\u308b\u8840\u5727\u3068\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5fdc\u3092\u6e2c\u5b9a\u3057\u305f\uff0e<\/p>\n
\u3000\u6211\u3005\u306f\u4e21\u8005\u306e\u53cd\u5fdc\u3092\u52a0\u7b97\u3057\u305f\u70b9\u6570\u3092\u767a\u5c55\u3055\u305b\u305f\uff0e\u8840\u5727\u306b\u95a2\u3057\u3066\u306f1\u70b9\u3092\u5e73\u5747\u8840\u5727 2 mm Hg \u672a\u6e80\u306e\u53cd\u5fdc\u3068\u3057\uff0c2\u70b92 mm Hg\u30683 mm Hg\u306e\u9593\uff0c3\u70b9\u30923 mm Hg \u3068 4 mm Hg \u306e\u9593\uff0c4\u70b9\u3092 4 mm Hg \u3068 5 mm Hg \u306e\u9593\uff0c5\u70b9\u3092 5 mm Hg \u3088\u308a\u5927\u3068\u3057\u305f\uff0e\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5fdc\u306b\u3064\u3044\u3066\u306f1\u70b9\u3092 2.5% \u672a\u6e80\u306e\u53cd\u5fdc\u3068\u3057\uff0c2\u70b9\u3092 2.5% \u3068 5% \u306e\u9593\uff0c3\u70b9\u3092 5% \u30687.5% \u306e\u9593\uff0c4\u70b9\u3092 7.5% \u3068 10% \u306e\u9593\uff0c5\u70b9\u3092 10% \u3088\u308a\u5927\u3068\u3057\u305f\uff0e\u6211\u3005\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u306f\uff0c\u8840\u5727\u3068\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5fdc\u306e\u5e73\u5747\u5024\uff08\u6a19\u6e96\u504f\u5dee\uff09\u306f\u5065\u5eb7\u306a\u7537\u5973\uff08\u305d\u308c\u305e\u308cn = 50\uff09\u306e\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066 L-\u30a2\u30eb\u30ae\u30cb\u30f3\u9759\u6ce8\u306b\u5f93\u3063\u3066\uff08\u57fa\u6e96\u5024\u306810 \u5206\u5024\u3068\u306e\u5dee\u7570\uff09\uff0c- 6.5 (1.5) mm Hg, – 13% (3%) \u305d\u308c\u305e\u308c\u4f4e\u4e0b\u3057\u305f\uff0e\u305d\u306e\u5bfe\u5fdc\u3059\u308b\u6700\u5927\u70b9\u6570\u306f 10 \u70b9\u3067\u3042\u3063\u305f\uff0e<\/p>\n
\u691c\u67fb\u89e3\u6790<\/h3>\n
\u3000\u7a7a\u8179\u6642\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u63a8\u5b9a\u5024\u306f\u6052\u5e38\u6027\u30e2\u30c7\u30eb\u8a55\u4fa1 (HOMA) \u306b\u3088\u308a\u8a55\u4fa1\u3055\u308c\uff0c\u4ee5\u4e0b\u306e\u5f0f\u3067\u8a08\u7b97\u3059\u308b\uff0e\u7a7a\u8179\u6642\u8840\u6f3f\u30b0\u30eb\u30b3\u30fc\u30b9\u6fc3\u5ea6 (mmol\/L) \u00d7\u7a7a\u8179\u6642\u8840\u6e05\u30a4\u30f3\u30b9\u30ea\u30f3\u5024 (microU\/mL) \/ 25\uff0e\u3053\u308c\u306fMatthews \u3089\u306e\u63d0\u5531\u306b\u3088\u308b\uff0e\u305d\u306e\u65b9\u6cd5\u3067\u306f HOMA \u70b9\u6570\u304c\u9ad8\u3044\u3053\u3068\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u304c\u4f4e\u3044\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3067\u3042\u308b\uff09\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\uff0e\u75c5\u9662\u306e\u81e8\u5e8a\u691c\u67fb\u5ba4\u306b\u304a\u3044\u3066\u8840\u6e05\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff0cHDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff0c\u4e2d\u6027\u8102\u80aa\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u6fc3\u5ea6\u3092\u6e2c\u5b9a\u3057\u305f\uff0e\u8840\u6f3f\u30a4\u30f3\u30b9\u30ea\u30f3\u6fc3\u5ea6\u306f\u30e9\u30b8\u30aa\u30a4\u30e0\u30ce\u30a2\u30c3\u30bb\u30a4\u6cd5\u306b\u3088\u308a\u6e2c\u5b9a\u3057\u305f (Ares, Serono, Italy)\uff0e<\/p>\n
\u3000\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u9ad8\u611f\u5ea6 CRP \u5024\u306e\u8840\u6e05\u6a19\u672c\u306f\u6e2c\u5b9a\u307e\u3067 \u2013 80 \u5ea6\u3067\u4fdd\u7ba1\u3057\u305f\uff0eIL-6, IL-7, IL-18 \u306e\u8840\u6e05\u6fc3\u5ea6\u306f\u9ad8\u611f\u5ea6\u306e\u5b9a\u91cf\u7684\u30b5\u30f3\u30c9\u30a4\u30c3\u30c1\u9175\u7d20\u30a2\u30c3\u30bb\u30a4\u6cd5 (Quantikine HS, R&D Systems, Minneapolis, Minn) \u3067\u91cd\u8907\u3057\u3066\u6c7a\u5b9a\u3057\u305f\uff0e\u9ad8\u611f\u5ea6 CRP \u306f Behring Nephelometer 2 (Dade Behring, Marburg, Germany) \u3092\u7528\u3044\u3066\u514d\u75ab\u6bd4\u6fc1\u6cd5\u306b\u3088\u308a\u6e2c\u5b9a\u3057\u305f\uff0e\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\uff0c\u5065\u5eb7\u306a\u7537\u5973 50 \u540d\u305a\u3064\u8a08 100 \u540d\u306e\u56db\u5206\u4f4d\u7bc4\u56f2\u306b\u304a\u3051\u308b\u4e2d\u592e\u5024\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\uff0e\u9ad8\u611f\u5ea6 CRP 0.7 mg\/L (0.2 \u2013 3.2 mg\/L), IL-6 2.1 pg\/mL (0.3 \u2013 5.2 pg\/mL), IL-7 1.8 pg\/mL (0.5 \u2013 5.2 pg\/mL), IL-18 129 pg\/mL (50 – 275 pg\/mL). <\/p>\n
\u7d71\u8a08\u89e3\u6790<\/h3>\n
\u3000\u30c7\u30fc\u30bf\u306f\u4ed6\u306b\u8a18\u8ff0\u304c\u306a\u3051\u308c\u3070\u5e73\u5747\u5024\uff08\u6a19\u6e96\u504f\u5dee\uff09\u3068\u3057\u3066\u8a18\u8ff0\u3059\u308b\uff0e\u30c7\u30fc\u30bf\u3092\u6cbb\u7642\u76ee\u7684\u306b\u3088\u308a\u89e3\u6790\u3057\u305f\uff0e\u6211\u3005\u306f\u9023\u7d9a\u5909\u6570\u306b\u306ft\u691c\u5b9a\u3092\uff0c\u9ad8\u611f\u5ea6 CRP, IL-6, IL-7, IL-18 \u306b\u306fWilcoxon \u30c6\u30b9\u30c8\u3092\u7528\u3044\u3066\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3092\u8a55\u4fa1\u3057\u305f\uff0e\u6211\u3005\u306f\u5168\u60a3\u8005\u3092\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e3,4,5\u306e\u8981\u7d20\u6570\u3067\u5206\u985e\u3057\uff0c\u9ad8\u611f\u5ea6 CRP \u4e2d\u592e\u5024\u3068 HOMA \u5e73\u5747\u5024\u3068\u306e\u95a2\u4fc2\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\uff0c\u3053\u308c\u3089\u306e\u7fa4\u306b\u307e\u305f\u304c\u308b\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\u3092 Jonckheere \u2013 Terpstra test \u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u305f\uff0e\u6211\u3005\u306f\u5371\u967a\u56e0\u5b50\u3068\u6804\u990a\u6442\u53d6\u91cf\u3092\u6bd4\u8f03\u3057\u305f\uff0c\u7d4c\u904e\u89b3\u5bdf\u671f\u9593\u306e\u7d42\u4e86\u6642\u70b9\u3067\u306e\u5024\u306b\u57fa\u304f\u30c6\u30b9\u30c8\u3092\u7528\u3044\u305f2\u5e74\u5f8c\u306b\uff0c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5dee\u7570\u306b\u57fa\u304f t-test \u3092\u7528\u3044\u3066\uff0e\u7d4c\u904e\u89b3\u5bdf\u671f\u9593\u4e2d\u306b\u8131\u843d\u3057\u305f\u60a3\u8005\u3092\u9664\u3044\u305f\u89e3\u6790\u306e\u7d50\u679c\u306f\uff0c\u8131\u843d\u3057\u305f\u60a3\u8005\u306e\u6700\u5f8c\u306b\u5f97\u3089\u308c\u305f\u8a18\u9332\u3092\u542b\u3081\u3066\u3082\u3055\u307b\u3069\u5909\u5316\u3057\u306a\u304b\u3063\u305f\uff0e\u305d\u308c\u6545\u5168\u60a3\u8005\u306e\u30c7\u30fc\u30bf\u3092\u542b\u3081\u3066\u7121\u4f5c\u70ba\u5316\u3068\u3057\u3066\u8868\u8a18\u3057\u305f\uff0eSpearman \u9806\u4f4d\u76f8\u95a2\u4fc2\u6570\u3092\u7528\u3044\u3066\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u5909\u6570\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\u306e\u95a2\u9023\u3092\u5b9a\u91cf\u5316\u3057\u305f\uff0eHOMA \u3068\u5185\u76ae\u6a5f\u80fd\u70b9\u6570\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\uff0c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5024\uff0c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u305d\u308c\u305e\u308c\u306e\u8981\u7d20\u306f\u5bfe\u5fdc\u306e\u3042\u308bt\u691c\u5b9a\u3068 Wilcoxon matched test \u3092\u7528\u3044\u3066\u4f53\u91cd\u5909\u5316\u3092\u8abf\u6574\u3057\u305f\u5f8c\u306b\u691c\u5b9a\u3057\u305f\uff0e\u6cbb\u7642\u5f8c\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3059\u308b2\u7fa4\u306b\u304a\u3051\u308b\u53c2\u52a0\u8005\u306e\u5272\u5408\u3092\u6bd4\u8f03\u3059\u308b\u306e\u306b\u03c7\u4e8c\u4e57\u691c\u5b9a\u3092\u7528\u3044\u305f\uff0eP < 0.05 \u3092\u7d71\u8a08\u7684\u6709\u610f\u3068\u307f\u306a\u3057\u305f\uff0e\u3059\u3079\u3066\u306e\u89e3\u6790\u306f SPSS 9.0 (SPSS inc, Chicago, Ill) \u3092\u7528\u3044\u3066\u5b9f\u65bd\u3057\u305f\uff0e<\/p>\n
\u7d50\u679c<\/h3>\n
\u3000180 \u540d\u306e\u60a3\u8005\u3092\u4ecb\u5165\u7fa4 (n = 90) \u304b\u5bfe\u7167\u7fa4 (n = 90) \u306b\u7121\u4f5c\u70ba\u5272\u4ed8\u3057\u305f (Figure 1<\/strong>)\uff0e\u4e21\u7fa4\u3068\u3082\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u3092\u542b\u3081\u3066\u540c\u7b49\u3067\u3042\u3063\u305f (Table 1<\/strong>)\uff0e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u304c\u5897\u3048\u308b\u306b\u3064\u308c\u3066\u9ad8\u611f\u5ea6 CRP \u5024\u3068 HOMA \u70b9\u6570\u304c\u5897\u52a0\u3057\u3066\u3044\u305f\uff0e\u4e00\u65b9\u3067\uff0c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u3068\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\u306e\u9593\u306b\u306f\u9006\u76f8\u95a2\u304c\u898b\u3089\u308c\u305f (\u3059\u3079\u3066\u306e\u50be\u5411\u306b\u304a\u3044\u3066 P < 0.001) (Figure 1<\/strong>)\uff0eSpearman \u9806\u4f4d\u76f8\u95a2\u4fc2\u6570\u306b\u3088\u308b\u3068\uff0c\u4ee5\u4e0b\u306e\u95a2\u9023\u306f\u5426\u5b9a\u7684\u3067\u3042\u3063\u305f\uff0e\u3064\u307e\u308a\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\u3068\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84 (r = – 0.30, P = 0.01), \u9ad8\u611f\u5ea6 CRP (r = – 0.33, P = 0.01), HOMA \u30b9\u30b3\u30a2 (r = – 0.24, P = 0.02)\uff0cIL-6 (r = – 0.21, P = 0.02)\uff0e<\/p>\n
\u30002\u5e74\u9593\u306e\u7d4c\u904e\u89b3\u5bdf\u5f8c\uff0c\u4ecb\u5165\u7fa4\u306e8\u540d\u3068\u5bfe\u7167\u7fa4\u306e8\u540d\u304c\u8a66\u9a13\u304b\u3089\u8131\u843d\u3057\u305f\uff0e\u8131\u843d\u8005\u306f\u5168\u54e1\u89b3\u5bdf\u958b\u59cb\u5f8c 24 \u9031\u4ee5\u964d\u3067\u3042\u3063\u305f\uff0e\u4ecb\u5165\u7fa4\u306e\u8131\u843d\u8005\u306f 24 \u9031\u306e\u89b3\u5bdf\u671f\u9593\u5f8c\u4f53\u91cd\u6e1b\u5c11\u3092\u8a8d\u3081\u3066\u304a\u308a\uff0c\u751f\u6d3b\u7fd2\u6163\u306e\u5909\u66f4\u3092\u9075\u5b88\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u305f\uff0e<\/p>\n
\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c7\u30fc\u30bf\u306f2\u7fa4\u9593\u3067\u306e\u6804\u990a\u6442\u53d6\u91cf\u306b\u91cd\u8981\u306a\u5dee\u7570\u304c\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b (Table 2<\/strong>)\uff0e2\u5e74\u5f8c\uff0c\u4ecb\u5165\u7fa4\u3067\u306f\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u4ee5\u4e0b\u306e\u50be\u5411\u304c\u898b\u3089\u308c\u305f\uff0e\u3059\u306a\u308f\u3061\u4e00\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u3068\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u304b\u3089\u306a\u308b\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u306e\u5897\u52a0\uff0c\u98df\u7269\u7e4a\u7dad\u6442\u53d6\u306e\u5897\u52a0\uff0c\u03c9-3 \u8102\u80aa\u9178\u306b\u5bfe\u3059\u308b\u03c9-6 \u8102\u80aa\u9178\u6442\u53d6\u91cf\u306e\u6e1b\u5c11\uff0c\u30a8\u30cd\u30eb\u30ae\u30fc\u30fb\u98fd\u548c\u8102\u80aa\u9178\u30fb\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6e1b\u5c11\uff0e\u679c\u5b9f\u985e\uff0c\u91ce\u83dc\u985e\uff0c\u30ca\u30c3\u30c4\u985e\uff0c\u5168\u7c92\u7a40\u7269\u306e\u6442\u53d6\u91cf\u3068\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306e\u6d88\u8cbb\u91cf\u306f\u4ecb\u5165\u7fa4\u306b\u304a\u3044\u3066\u8457\u660e\u306b\u5897\u52a0\u3057\u3066\u3044\u305f (Table 2<\/strong>)\uff0e\u904b\u52d5\u91cf\u306f\u4e21\u7fa4\u3068\u3082\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\uff08\u4ecb\u5165\u7fa4 48 [SD, 10] \u5206\u9593\uff0f\u9031\u304b\u3089 84 [SD, 36] \u5206\u9593\uff0f\u9031\uff0cP < 0.001\uff0e\u5bfe\u7167\u7fa4 51 [SD, 9] \u5206\u9593\uff0f\u9031\u304b\u3089 81 [SD, 38] \u5206\u9593\uff0f\u9031\uff0cP < 0.001\uff09\uff0e\u4e21\u7fa4\u9593\u3067\u306e\u5dee\u7570\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f (P = 0.22)\uff0e<\/p>\n
\u30002\u5e74\u5f8c\uff0c\u4ecb\u5165\u7fa4\u306e\u60a3\u8005\u306f\u4f53\u91cd\uff0cBMI, \u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\uff0cHOMA \u30b9\u30b3\u30a2\uff0c\u8840\u5727\uff0c\u8840\u7cd6\u5024\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u5024\uff0c\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff0c\u4e2d\u6027\u8102\u80aa\u5024\u306e\u8457\u660e\u306a\u6e1b\u5c11\u3092\u8a8d\u3081\uff0cHDL \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff0c\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066\u8a18\u9332\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u5024\u306b\u304a\u3044\u3066\u8457\u660e\u306a\u5897\u52a0\u3092\u8a8d\u3081\u305f (Table 3<\/strong>)\uff0e\u6027\u5225\u3067\u306e\u5dee\u7570\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\uff0eIL-6, IL-7, IL-18, \u9ad8\u611f\u5ea6 CRP \u306e\u4ecb\u5165\u7fa4\u3067\u306e\u8840\u6e05\u6fc3\u5ea6\u306f\u5bfe\u7167\u7fa4\u306e\u305d\u308c\u3068\u6bd4\u8f03\u3057\u3066\u8457\u660e\u306b\u6e1b\u5c11\u3057\u3066\u3044\u305f\uff0e\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\u306f\u4ecb\u5165\u7fa4\u306b\u304a\u3044\u3066\u306f\u6539\u5584\u3092\u8a8d\u3081\u305f\u304c\u5bfe\u7167\u7fa4\u3067\u306f\u5909\u5316\u3057\u306a\u304b\u3063\u305f\uff0e\u5185\u76ae\u6a5f\u80fd\u30b9\u30b3\u30a2\u3068\u9ad8\u611f\u5ea6 CRP \u5024(r = – 0.36, P < 0.01) \u304a\u3088\u3073 HOMA \u30b9\u30b3\u30a2 (r = - 0.31, P = 0.01) \u306e\u9593\u306b\u306f\u8ca0\u306e\u76f8\u95a2\u304c\u898b\u3089\u308c\u305f\uff0e<\/p>\n
\u30002\u5e74\u9593\u306e\u89b3\u5bdf\u671f\u9593\u5f8c\u306e\u6642\u70b9\u306b\u304a\u3044\u3066\u4ecb\u5165\u7fa4\u306e 60 \u540d\u306e\u53c2\u52a0\u8005\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u306e\u6e1b\u5c11\u3092\u7d4c\u9a13\u3057 (Table 3<\/strong>), 40 \u540d\u304c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u307e\u307e\u3068\u5206\u985e\u3055\u308c\u305f\u306b\u904e\u304e\u306a\u304b\u3063\u305f\uff0e\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066\u306f\u5927\u304d\u304f\u69d8\u76f8\u306f\u7570\u306a\u308a\uff0c78 \u540d\u306e\u60a3\u8005\u304c\u672a\u3060\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3057\u3066\u3044\u308b\u3068\u5206\u985e\u3055\u308c\u305f (P < 0.001)\uff0e\u4f53\u91cd\u5909\u5316\u306e\u8abf\u6574\u524d\u306e\u30c7\u30fc\u30bf\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u306e\u8457\u660e\u306a\u6e1b\u5c11\u3092\u793a\u3057\uff0c2\u5e74\u9593\u306e\u89b3\u5bdf\u671f\u9593\u5f8c\u306e\u6642\u70b9\u3067\u306f\u4ecb\u5165\u7fa4\u3067 30 \u540d\uff0c\u5bfe\u7167\u7fa4\u3067 73 \u540d\u304c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3057\u3066\u3044\u308b\u3068\u5206\u985e\u3055\u308c\u305f\uff0e<\/p>\n
\u30b3\u30e1\u30f3\u30c8<\/h3>\n
\u3000\u672c\u8a66\u9a13\u306b\u304a\u3044\u3066\u306f\uff0c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u3088\u308b\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306e\u6d88\u8cbb\u306f\u5185\u76ae\u6a5f\u80fd\u306e\u6539\u5584\u3068\u5168\u8eab\u8840\u7ba1\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u306e\u8457\u660e\u306a\u6e1b\u5c11\u306b\u95a2\u4fc2\u3057\u3066\u3044\u305f\uff0e\u66f4\u306b\uff0c\u4ecb\u5165\u98df\u306b\u5f93\u4e8b\u3057\u305f\u53c2\u52a0\u8005\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u8981\u7d20\u6570\u306e\u6e1b\u5c11\u3092\u8a8d\u3081\uff0c\u5168\u4f53\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u6709\u75c5\u7387\u306f\u7d04\u534a\u5206\u306b\u6e1b\u5c11\u3057\u305f\uff0e\u4f53\u91cd\u3067\u30c7\u30fc\u30bf\u3092\u8abf\u6574\u3057\u305f\u305f\u3081\uff0c\u4ecb\u5165\u5f8c\u306e\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u5168\u4f53\u306e\u6709\u75c5\u7387\u306e\u6e1b\u5c11\u306f\u4fdd\u5b88\u7684\u306a\u6e2c\u5b9a\u3092\u8868\u3059\uff0e\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u5171\u306b\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u304c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u6cbb\u7642\u306b\u5b89\u5168\u306a\u6226\u7565\u3067\u3042\u308a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n
\u3000\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u500b\u3005\u306e\u8981\u7d20\u306b\u5bfe\u3059\u308b\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u751f\u6d3b\u7fd2\u6163\u306e\u4fee\u98fe\uff08\u4f53\u91cd\u306e\u6e1b\u91cf\u3068\u904b\u52d5\uff09\u3092\u4e00\u6b21\u6cbb\u7642\u3068\u3057\u3066\u5f37\u8abf\u3057\u3066\u304a\u308a\uff0c\u4e00\u65b9\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u6307\u793a\u3057\u306a\u3044\u9650\u308a\u85ac\u7269\u6cbb\u7642\u306f\u4e8c\u6b21\u6cbb\u7642\u3068\u307f\u306a\u3055\u308c\u3066\u3044\u308b (22)\uff0e\u6211\u3005\u306e\u8a66\u9a13\u3067\u306f\uff0c\u4ecb\u5165\u98df\u306e\u52b9\u679c\u306f\u4f53\u91cd\u5909\u5316\u306b\u306f\u63a7\u3048\u3081\u306a\u95a2\u4fc2\u3092\u793a\u3057\u3066\u3044\u305f\u304c\uff0cCRP \u5024\u306b\u306f\u52b9\u679c\u304c\u306a\u304f\uff0c\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066\u904b\u52d5\u3092\u5897\u91cf\u3057\u3066\u3082\u5909\u5316\u304c\u306a\u304b\u3063\u305f\u306e\u3068\u540c\u69d8\u3067\u3042\u3063\u305f (23)\uff0e\u4f53\u91cd\u5909\u5316\u3067\u7d50\u679c\u3092\u8abf\u6574\u3057\u305f\u305f\u3081\uff0c\u6211\u3005\u306e\u6240\u898b\u306f\uff0c\u4f53\u91cd\u306e\u540c\u6642\u5909\u5316\u306f\u5927\u304d\u304f\u72ec\u7acb\u3057\u3066\u304a\u308a\uff0c\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u306f\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306b\u95a2\u9023\u3059\u308b\u708e\u75c7\u72b6\u614b\u3068\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3092\u6e1b\u5c11\u3055\u305b\u308b\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n
\u3000\u5730\u4e2d\u6d77\u5f0f\u6599\u7406\u304c\u3044\u304b\u306a\u308b\u6a5f\u5e8f\u3067\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u306b\u95a2\u9023\u3059\u308b\u708e\u75c7\u72b6\u614b\u3092\u6e1b\u5c11\u3055\u305b\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u5206\u304b\u3063\u3066\u3044\u306a\u3044\uff0e\u4e3b\u8981\u6804\u990a\u7d20\u306e\u6442\u53d6\u304c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u7269\u8cea\u3092\u751f\u3058\u3066\u524d\u708e\u75c7\u72b6\u614b\u306b\u81f3\u308b (24)\uff0e\u3053\u306e\u8208\u5473\u6df1\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\uff0c\u5065\u5eb7\u306a\u500b\u4eba\u304c\u9ad8\u8102\u80aa\u98df\u3092\u98df\u3079\u305f\u5f8c\uff0c\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3 (25, 26) \u3084\u98df\u7269\u306e\u6297\u9178\u5316\u7269\u8cea (20) \u304c\u4e00\u904e\u6027\u306e\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u306b\u3088\u308a\u652f\u6301\u3055\u308c\u3066\u3044\u308b\uff0e\u66f4\u306b\uff0c\u98df\u4e8b\u4e2d\u306e\u98df\u7269\u7e4a\u7dad\u542b\u6709\u306e\u4fee\u98fe\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u74b0\u5883\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u9ad8\u70ad\u6c34\u5316\u7269\u98df\u306b\u304a\u3051\u308b\u98df\u7269\u7e4a\u7dad\u542b\u6709\u306e\u4e0a\u6607 \uff084.5 g \u304b\u3089 16.8 g\uff09\u306f\uff0c\u5065\u5eb7\u306a\u4eba\u306b\u304a\u3044\u3066\u30822\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\uff0c\u5faa\u74b0\u8840\u6f3f\u4e2d\u306e IL-18 \u5024\u306e\u6e1b\u5c11\u306b\u95a2\u4fc2\u3059\u308b (27)\uff0e\u98df\u7269\u7e4a\u7dad\u304c\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\uff0c\u6700\u4f4e\u3067\u3082\u8178\u7ba1\u6a5f\u80fd\u306b\u304a\u3044\u3066\u306f\uff0c\u4ecb\u5165\u98df\u306b\u304a\u3051\u308b\u98df\u7269\u7e4a\u7dad\u306e\u542b\u6709\u306f\uff0c\u6700\u7d42\u7684\u306b\u306f\u4ed6\u306e\u5e7e\u3064\u304b\u306e\u6297\u9178\u5316\u6a5f\u80fd\u3092\u6709\u3059\u308b\u8981\u7d20\u306b\u62e1\u5927\u3057\u305f\u3068\u3057\u3066\u3082\uff0c\u4e3b\u8981\u6804\u990a\u7d20\u306e\u6d88\u5316\u5f8c\u306b\u4e00\u904e\u6027\u306b\u767a\u751f\u3059\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u7269\u8cea\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u03c9-3 \u8102\u80aa\u9178\u306e\u6297\u708e\u75c7\u4f5c\u7528\u304c\u793a\u5506\u3055\u308c\u305f\u304c\uff0c\u3053\u306e\u52b9\u679c\u306e\u5927\u90e8\u5206\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f7f\u7528\u3067\u898b\u3089\u308c\u308b\u3082\u306e\u3067\u3042\u308b\uff0e<\/p>\n
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