\u3000\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u5316\u5b66\u540d\u306f\u30ea\u30dc\u30d5\u30e9\u30d3\u30f3\u3067\u98df\u4e8b\u6442\u53d6\u57fa\u6e96\u306f\u30b7\u30dc\u30d5\u30e9\u30d3\u30f3\u91cf\u3068\u3057\u3066\u8a2d\u5b9a\u3055\u308c\u307e\u3057\u305f\uff0e\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306b\u30ea\u30f3\u9178\u304c\u4e00\u3064\u7d50\u5408\u3057\u305f\u30d5\u30e9\u30d3\u30f3\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9 (FMN) \u305d\u308c\u306b AMP \u304c\u7d50\u5408\u3057\u305f\u30d5\u30e9\u30d3\u30f3\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9 (FAD) \u306f\u5171\u306b\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306b\u6d88\u5316\u3055\u308c\u3066\u5438\u53ce\u3055\u308c\u308b\u305f\u3081\uff0c\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u3068\u5f53\u30e2\u30eb\u306e\u6d3b\u6027\u3092\u793a\u3057\u307e\u3059\uff0e<\/p>\n}}}}

\u3000\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306f\u88dc\u9175\u7d20 FMN \u304a\u3088\u3073 FAD \u3068\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u7269\u8cea\u4ee3\u8b1d\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\uff0eTCA \u56de\u8def\uff0c\u96fb\u5b50\u4f1d\u9054\u7cfb\uff0c\u8102\u80aa\u9178\u306e β \u9178\u5316\u306a\u3069\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u95a2\u308f\u3063\u3066\u304a\u308a\uff0c\u30d3\u30bf\u30df\u30f3 B _{2<\/sub> \u304c\u6b20\u4e4f\u3059\u308b\u3068\u6210\u9577\u6291\u5236\uff0c\u53e3\u5185\u708e\uff0c\u53e3\u89d2\u708e\uff0c\u820c\u708e\uff0c\u8102\u6f0f\u6027\u76ae\u819a\u708e\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\uff0e<\/p>\n}}

\u3000\u98df\u54c1\u4e2d\u306e\u30ea\u30dc\u30d5\u30e9\u30d3\u30f3\u306f\u5927\u534a\u304c FAD \u3084 FMN \u3068\u3057\u3066\u5b58\u5728\u3057\u3066\u304a\u308a\uff0c\u8abf\u7406\u30fb\u80c3\u9178\u306e\u5f71\u97ff\u306b\u3088\u308aFAD, FMN \u306f\u904a\u96e2\u3057\u307e\u3059\uff0e\u904a\u96e2\u3057\u305f FAD, FMN \u306f\u5c0f\u8178\u7c98\u819c\u306e FMN \u30d5\u30a9\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u304a\u3088\u3073 FAD \u30d4\u30ed\u30d5\u30a9\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u306b\u3088\u308a\u52a0\u6c34\u5206\u89e3\u3055\u308c\u3066\u30ea\u30dc\u30d5\u30e9\u30d3\u30f3\u306b\u306a\u308a\uff0c\u5c0f\u8178\u4e0a\u76ae\u7d30\u80de\u304b\u3089\u80fd\u52d5\u8f38\u9001\u306b\u3088\u308a\u5438\u53ce\u3055\u308c\u307e\u3059\uff0e\u65e5\u672c\u4eba\u306b\u304a\u3051\u308b\u98df\u4e8b\u4e2d\u306e\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u76f8\u5bfe\u751f\u4f53\u5229\u7528\u7387\u306f 64 % \u3068\u5831\u544a<\/a>\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n}

\u3000\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u5fc5\u8981\u91cf\u3092\u6c42\u3081\u308b\u65b9\u6cd5\u306b\u306f\uff0c\u6b20\u4e4f\u75c7\u304b\u3089\u306e\u56de\u5fa9\u306b\u5fc5\u8981\u306a\u6700\u5c0f\u91cf\u3068\uff0c\u6442\u53d6\u91cf\u3068\u5c3f\u4e2d\u6392\u6cc4\u91cf\u3068\u306e\u95a2\u4fc2\u5f0f\u306b\u3088\u308b\u5909\u66f2\u70b9\u3068\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u4e21\u8005\u306e\u5024\u306f\u7570\u306a\u308a\u307e\u3059\uff0e\u3053\u3053\u3067\u306f\u6c34\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u306f\u5fc5\u8981\u91cf\u3092\u6e80\u305f\u3059\u307e\u3067\u306f\u5c3f\u4e2d\u306b\u6392\u6cc4\u3055\u308c\u305a\uff0c\u5fc5\u8981\u91cf\u3092\u8d85\u3048\u308b\u3068\u6025\u6fc0\u306b\u5c3f\u4e2d\u6392\u6cc4\u91cf\u304c\u5897\u5927\u3059\u308b\u3068\u306e\u8003\u3048\u304b\u3089\uff0c\u5909\u66f2\u70b9\u3092\u5fc5\u8981\u91cf\u3068\u3059\u308b\u3053\u3068\u3068\u3057\u307e\u3059\uff0e}\u6442\u53d6\u91cf\u304c 1.1 mg\/d \u3092\u8d85\u3048\u308b\u3068\u6442\u53d6\u91cf\u306b\u4f9d\u5b58\u3057\u3066\u5c3f\u4e2d\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u6392\u6cc4\u91cf\u304c\u5897\u5927\u3059\u308b (pdf)<\/a>\u3053\u3068\u304b\u3089\uff0c\u3053\u308c\u3092\u5fc5\u8981\u91cf\u3068\u8003\u3048\u307e\u3059\uff0e<\/p>\n}

\u6210\u4eba\u30fb\u5c0f\u5150\u306e\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u30fb\u63a8\u5968\u91cf<\/h3>\n
\u3000\u30d3\u30bf\u30df\u30f3 B_{1<\/sub> \u3068\u540c\u3058\u304f\uff0c\u5c3f\u4e2d\u306b\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u6392\u6cc4\u91cf\u304c\u5897\u52a0\u3057\u59cb\u3081\u308b\u6700\u5c0f\u6442\u53d6\u91cf\u3092\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u3068\u3057\u307e\u3057\u305f\uff0e\u5b9f\u9a13\u6642\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u304c 2,200 kcal\/d \u3067\u3042\u3063\u305f\u305f\u3081\uff0c1-69 \u6b73\u306b\u304a\u3051\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u3042\u305f\u308a\u306e\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u3092\u7b97\u5b9a\u3059\u308b\u305f\u3081\u306e\u53c2\u7167\u5024\u306f 0.50 mg\/1,000 kcal \u3067\u3059\uff0e\u3053\u306e\u53c2\u7167\u5024\u306b\u5e74\u9f62\u533a\u5206\u3054\u3068\u306e\u63a8\u5b9a\u30a8\u30cd\u30eb\u30ae\u30fc\u5fc5\u8981\u91cf\u3092\u4e57\u3058\u3066\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u3092\u7b97\u5b9a\u3057\u307e\u3057\u305f\uff0e\u63a8\u5968\u91cf\u306f\uff0c\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u306b\u63a8\u5968\u91cf\u7b97\u5b9a\u4fc2\u6570 1.2 \u3092\u4e57\u3058\u307e\u3057\u305f\uff0e<\/p>\n}}
\u598a\u5a66\u306e\u4ed8\u52a0\u91cf\u306e\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u30fb\u63a8\u5968\u91cf<\/h3>\n
\u3000\u598a\u5a66\u306e\u4ed8\u52a0\u91cf\u306f\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u8981\u6c42\u91cf\u306b\u5fdc\u3058\u3066\u5897\u5927\u3059\u308b\u3053\u3068\u304b\u3089\u7b97\u5b9a\u3057\u307e\u3057\u305f\uff0e\u598a\u5a20\u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ed8\u52a0\u91cf\u306f\u521d\u671f\u3067 50 kcal\/d \u4e2d\u671f\u3067 250 kcal\/d, \u5f8c\u671f\u3067 450 kcal\/d \u3067\u3059\u304c\uff0c\u3053\u308c\u3089\u306b\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u306e\u53c2\u7167\u5024 0.50 mg\/1,000 kcal \u3092\u4e57\u3058\u308b\u3068\u521d\u671f\u306f 0.03 mg\/d \u4e2d\u671f\u306f 0.13 mg\/d, \u5f8c\u671f\u306f 0.23 mg\/d \u3068\u306a\u308a\u307e\u3059\uff0e\u3057\u304b\u3057\u598a\u5a20\u671f\u306f\u500b\u4eba\u306b\u3088\u308a\u30a8\u30cd\u30eb\u30ae\u30fc\u8981\u6c42\u91cf\u304c\u7570\u306a\u308a\uff0c\u598a\u5a20\u4e2d\u306f\u7279\u306b\u4ee3\u8b1d\u304c\u4ea2\u9032\u3059\u308b\u305f\u3081\uff0c\u598a\u5a20\u5f8c\u671f\u306e\u5024\u3092\u5168\u598a\u5a20\u671f\u9593\u306e\u5fc5\u8981\u91cf\u3068\u3057\u307e\u3057\u305f\uff0e\u598a\u5a66\u306e\u4ed8\u52a0\u91cf\u306e\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u306f\u4e38\u3081\u3066 0.2 mg\/d \u3068\u3057\uff0c\u63a8\u5968\u91cf\u306f 0.3 mg\/d \u3068\u3057\u307e\u3057\u305f\uff0e<\/p>\n}
\u6388\u4e73\u5a66\u306e\u4ed8\u52a0\u91cf\u306e\u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf\u30fb\u63a8\u5968\u91cf<\/h3>\n
\u3000\u6388\u4e73\u5a66\u306e\u4ed8\u52a0\u91cf\u306f\uff0c\u6bcd\u4e73\u4e2d\u306e\u6fc3\u5ea6 0.40 mg\/L \u306b\u6ccc\u4e73\u91cf 0.78 L\/d \u3092\u4e57\u3058\uff0c\u76f8\u5bfe\u751f\u4f53\u5229\u7528\u7387 60 % \u3067\u9664\u3057\u3066\u7b97\u51fa\u3057\uff0c0.5 mg\/d \u3068\u3057\u307e\u3057\u305f\uff0e<\/p>\n
\u4e73\u5150\u306e\u76ee\u5b89\u91cf<\/h3>\n
\u30000-5 \u30f6\u6708\u5150\u306e\u4e73\u5150\u306e\u76ee\u5b89\u91cf\u306f\u6bcd\u4e73\u4e2d\u306e\u6fc3\u5ea6 0.40 mg\/L \u306b\u57fa\u6e96\u54fa\u4e73\u91cf 0.78 L\/d \u3092\u4e57\u3058\u3066 0.31 mg\/d \u3068\u306a\u308a\uff0c\u4e38\u3081\u3066 0.3 mg\/d \u3068\u3057\u307e\u3057\u305f\uff0e6-11 \u30f6\u6708\u5150\u306e\u76ee\u5b89\u91cf\u306f 0.4 mg\/d \u3068\u3057\u307e\u3057\u305f\uff0e<\/p>\n
\u3000\u30ea\u30dc\u30d5\u30e9\u30d3\u30f3\u306f\u904e\u5270\u91cf\u304c\u5438\u53ce\u3055\u308c\u3066\u3082\u4f59\u5270\u306f\u901f\u3084\u304b\u306b\u5c3f\u4e2d\u306b\u6392\u6cc4\u3055\u308c\u904e\u5270\u6442\u53d6\u306b\u3088\u308b\u5f71\u97ff\u3092\u53d7\u3051\u306b\u304f\u3044\u305f\u3081\uff0c\u8010\u7528\u4e0a\u9650\u91cf\u306f\u8a2d\u5b9a\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff0e<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u98df\u4e8b\u6442\u53d6\u57fa\u6e96 (mg\/d) \uff082015 \u5e74\u7248\uff09<\/caption>\n\n}
\u6027\u5225<\/th>\n \u7537\u6027<\/th>\n \u5973\u6027<\/th>\n<\/tr>\n
\u5e74\u9f62<\/th>\n \u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf<\/th>\n \u63a8\u5968\u91cf<\/th>\n \u76ee\u5b89\u91cf<\/th>\n \u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf<\/th>\n \u63a8\u5968\u91cf<\/th>\n \u76ee\u5b89\u91cf<\/th>\n<\/tr>\n<\/theader>\n
0-5 M<\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n<\/tr>\n
6-11 M<\/td>\n <\/td>\n <\/td>\n 0.4<\/td>\n <\/td>\n <\/td>\n 0.4<\/td>\n<\/tr>\n
1-2<\/td>\n 0.5<\/td>\n 0.6<\/td>\n <\/td>\n 0.5<\/td>\n 0.5<\/td>\n <\/td>\n<\/tr>\n
3-5<\/td>\n 0.7<\/td>\n 0.8<\/td>\n <\/td>\n 0.6<\/td>\n 0.8<\/td>\n <\/td>\n<\/tr>\n
6-7<\/td>\n 0.8<\/td>\n 0.9<\/td>\n <\/td>\n 0.7<\/td>\n 0.9<\/td>\n <\/td>\n<\/tr>\n
8-9<\/td>\n 0.9<\/td>\n 1.1<\/td>\n <\/td>\n 0.9<\/td>\n 1.0<\/td>\n <\/td>\n<\/tr>\n
10-11<\/td>\n 1.1<\/td>\n 1.4<\/td>\n <\/td>\n 1.1<\/td>\n 1.3<\/td>\n <\/td>\n<\/tr>\n
12-14<\/td>\n 1.3<\/td>\n 1.6<\/td>\n <\/td>\n 1.2<\/td>\n 1.4<\/td>\n <\/td>\n<\/tr>\n
15-17<\/td>\n 1.4<\/td>\n 1.7<\/td>\n <\/td>\n 1.2<\/td>\n 1.4<\/td>\n <\/td>\n<\/tr>\n
18-29<\/td>\n 1.3<\/td>\n 1.6<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
30-49<\/td>\n 1.3<\/td>\n 1.6<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
50-69<\/td>\n 1.2<\/td>\n 1.5<\/td>\n <\/td>\n 1.0<\/td>\n 1.1<\/td>\n <\/td>\n<\/tr>\n
70-<\/td>\n 1.1<\/td>\n 1.3<\/td>\n <\/td>\n 0.9<\/td>\n 1.1<\/td>\n <\/td>\n<\/tr>\n
\u598a\u5a66\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.2<\/td>\n 0.3<\/td>\n <\/td>\n<\/tr>\n
\u6388\u4e73\u5a66\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n 0.6<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u30d3\u30bf\u30df\u30f3 B_{2<\/sub> \u306e\u98df\u4e8b\u6442\u53d6\u57fa\u6e96 (mg\/d) \uff082010 \u5e74\u7248\uff09<\/caption>\n\n}
\u6027\u5225<\/th>\n \u7537\u6027<\/th>\n \u5973\u6027<\/th>\n<\/tr>\n
\u5e74\u9f62<\/th>\n \u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf<\/th>\n \u63a8\u5968\u91cf<\/th>\n \u76ee\u5b89\u91cf<\/th>\n \u63a8\u5b9a\u5e73\u5747\u5fc5\u8981\u91cf<\/th>\n \u63a8\u5968\u91cf<\/th>\n \u76ee\u5b89\u91cf<\/th>\n<\/tr>\n<\/theader>\n
0-5 M<\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n<\/tr>\n
6-11 M<\/td>\n <\/td>\n <\/td>\n 0.4<\/td>\n <\/td>\n <\/td>\n 0.4<\/td>\n<\/tr>\n
1-2<\/td>\n 0.5<\/td>\n 0.6<\/td>\n <\/td>\n 0.5<\/td>\n 0.5<\/td>\n <\/td>\n<\/tr>\n
3-5<\/td>\n 0.7<\/td>\n 0.8<\/td>\n <\/td>\n 0.6<\/td>\n 0.8<\/td>\n <\/td>\n<\/tr>\n
6-7<\/td>\n 0.8<\/td>\n 0.9<\/td>\n <\/td>\n 0.7<\/td>\n 0.9<\/td>\n <\/td>\n<\/tr>\n
8-9<\/td>\n 0.9<\/td>\n 1.1<\/td>\n <\/td>\n 0.9<\/td>\n 1.0<\/td>\n <\/td>\n<\/tr>\n
10-11<\/td>\n 1.1<\/td>\n 1.4<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
12-14<\/td>\n 1.3<\/td>\n 1.5<\/td>\n <\/td>\n 1.1<\/td>\n 1.4<\/td>\n <\/td>\n<\/tr>\n
15-17<\/td>\n 1.4<\/td>\n 1.7<\/td>\n <\/td>\n 1.1<\/td>\n 1.4<\/td>\n <\/td>\n<\/tr>\n
18-29<\/td>\n 1.3<\/td>\n 1.6<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
30-49<\/td>\n 1.3<\/td>\n 1.6<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
50-69<\/td>\n 1.2<\/td>\n 1.5<\/td>\n <\/td>\n 1.0<\/td>\n 1.2<\/td>\n <\/td>\n<\/tr>\n
70-<\/td>\n 1.1<\/td>\n 1.3<\/td>\n <\/td>\n 0.9<\/td>\n 1.1<\/td>\n <\/td>\n<\/tr>\n
\u598a\u5a20\u521d\u671f\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.0<\/td>\n 0.0<\/td>\n <\/td>\n<\/tr>\n
\u598a\u5a20\u4e2d\u671f\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.1<\/td>\n 0.2<\/td>\n <\/td>\n<\/tr>\n
\u598a\u5a20\u5f8c\u671f\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.2<\/td>\n 0.3<\/td>\n <\/td>\n<\/tr>\n
\u6388\u4e73\u5a66\u4ed8\u52a0\u91cf<\/td>\n <\/td>\n <\/td>\n <\/td>\n 0.3<\/td>\n 0.4<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\u53c2\u7167\uff1a<\/ br>
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